Ontology highlight
ABSTRACT:
SUBMITTER: Estrella NL
PROVIDER: S-EPMC4294490 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Estrella Nelsa L NL Desjardins Cody A CA Nocco Sarah E SE Clark Amanda L AL Maksimenko Yevgeniy Y Naya Francisco J FJ
The Journal of biological chemistry 20141121 2
Skeletal muscle differentiation requires precisely coordinated transcriptional regulation of diverse gene programs that ultimately give rise to the specialized properties of this cell type. In Drosophila, this process is controlled, in part, by MEF2, the sole member of an evolutionarily conserved transcription factor family. By contrast, vertebrate MEF2 is encoded by four distinct genes, Mef2a, -b, -c, and -d, making it far more challenging to link this transcription factor to the regulation of ...[more]