Ontology highlight
ABSTRACT:
SUBMITTER: Rizvi S
PROVIDER: S-EPMC4294543 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Seminars in liver disease 20141104 4
Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy with limited treatment options and low survival rates. Currently, there are no curative medical therapies for CCA. Recent advances have enhanced our understanding of the genetic basis of this disease, and elucidated therapeutically relevant targets. Therapeutic efforts in development are directed at several key pathways due to genetic aberrations including receptor tyrosine kinase pathways, mutant IDH enzymes, the PI3K-AKT-mTOR p ...[more]