Ontology highlight
ABSTRACT:
SUBMITTER: Niederst ED
PROVIDER: S-EPMC4294669 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Niederst Emily D ED Reyna Sol M SM Goldstein Lawrence S B LS
Molecular biology of the cell 20141112 2
Deposition of potentially neurotoxic Aβ fragments derived from amyloid precursor protein (APP) at synapses may be a key contributor to Alzheimer's disease. However, the location(s) of proteolytic processing and subsequent secretion of APP fragments from highly compartmentalized, euploid neurons that express APP and processing enzymes at normal levels is not well understood. To probe the behavior of endogenous APP, particularly in human neurons, we developed a system using neurons differentiated ...[more]