Illustration of a measure to combine viral suppression and viral rebound in studies of HIV therapy.
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ABSTRACT:
SUBMITTER: Edwards JK
PROVIDER: S-EPMC4294958 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Illustration of a measure to combine viral suppression and viral rebound in studies of HIV therapy.
Edwards Jessie K JK Cole Stephen R SR Adimora Adaora A Fine Jason J Martin Jeff J Eron Joseph J
Journal of acquired immune deficiency syndromes (1999) 20150201 2
Viral load is an important tool for assessing antiretroviral treatment efficacy. However, the most common viral load end point, virologic failure, may be flawed. We illustrate an alternative end point that estimates the average time patients spent suppressed before rebound in the AIDS Clinical Trials Group A5095 trial. Patients averaged 644 days suppressed in the 3-drug arm and 686 days suppressed in the 4-drug arm, for a difference of 42 days in favor of the 4-drug regimen (95% confidence inter ...[more]
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