Ontology highlight
ABSTRACT:
SUBMITTER: Jay J
PROVIDER: S-EPMC4295371 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Jay Jennifer J Hammer Alan A Nestor-Kalinoski Andrea A Diakonova Maria M
Molecular and cellular biology 20141020 1
JAK2 is a cytoplasmic tyrosine kinase critical for cytokine signaling. In this study, we have identified a novel centrosome-associated complex containing ninein and JAK2. We have found that active JAK2 localizes around the mother centrioles, where it partly colocalizes with ninein, a protein involved in microtubule (MT) nucleation and anchoring. We demonstrated that JAK2 is an important regulator of centrosome function. Depletion of JAK2 or use of JAK2-null cells causes defects in MT anchoring a ...[more]