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Ewing sarcoma of the posterior fossa in an adolescent girl.

ABSTRACT: Medulloblastoma, astrocytoma, and ependymoma represent the most common infratentorial tumors in childhood, while Ewing sarcomas in that localization are extremely rare. A large left infratentorial space-occupying lesion was diagnosed in a 12-year-old girl with signs of increased intracranial pressure. Following total tumor resection, histological and molecular examination revealed Ewing sarcoma with rearranged EWSR-1 gene. The patient achieved complete remission following adjuvant chemotherapy and radiotherapy according to Euro-EWING 2008 treatment protocol. Intracranial Ewing sarcoma, although rare, should be an important differential diagnosis of intracranial tumors in childhood which requires aggressive multimodal treatment.

SUBMITTER: Stark AM

PROVIDER: S-EPMC4295441 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Ewing sarcoma of the posterior fossa in an adolescent girl.

Stark Andreas M AM Leuschner Ivo I Mehdorn H Maximilian HM Claviez Alexander A

Case reports in medicine 20141229

Medulloblastoma, astrocytoma, and ependymoma represent the most common infratentorial tumors in childhood, while Ewing sarcomas in that localization are extremely rare. A large left infratentorial space-occupying lesion was diagnosed in a 12-year-old girl with signs of increased intracranial pressure. Following total tumor resection, histological and molecular examination revealed Ewing sarcoma with rearranged EWSR-1 gene. The patient achieved complete remission following adjuvant chemotherapy a ...[more]

PMID: 25614743

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