Ontology highlight
ABSTRACT:
SUBMITTER: Smith CM
PROVIDER: S-EPMC4296013 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Smith Clare M CM Jerkovic Ante A Puy Hervé H Winship Ingrid I Deybach Jean-Charles JC Gouya Laurent L van Dooren Giel G Goodman Christopher Dean CD Sturm Angelika A Manceau Hana H McFadden Geoffrey Ian GI David Peter P Mercereau-Puijalon Odile O Burgio Gaétan G McMorran Brendan J BJ Foote Simon J SJ
Blood 20141120 3
Many red cell polymorphisms are a result of selective pressure by the malarial parasite. Here, we add another red cell disease to the panoply of erythrocytic changes that give rise to resistance to malaria. Erythrocytes from individuals with erythropoietic protoporphyria (EPP) have low levels of the final enzyme in the heme biosynthetic pathway, ferrochelatase. Cells from these patients are resistant to the growth of Plasmodium falciparum malarial parasites. This phenomenon is due to the absence ...[more]