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Progress toward curing HIV infections with hematopoietic stem cell transplantation.

ABSTRACT: Combination antiretroviral therapy can suppress human immunodeficiency virus (HIV) infection but cannot completely eradicate the virus. A major obstacle in the quest for a cure is the difficulty in targeting and measuring latently infected cells. To date, a single person seems to have been cured of HIV. Hematopoietic stem cell transplantation (HSCT) preceded this cancer patient's long-term sustained HIV remission, but researchers have been unable to replicate this cure, and the mechanisms that led to HIV remission remain to be established. In February 2014, the National Institute of Allergy and Infectious Diseases sponsored a workshop that provided a venue for in-depth discussion of whether HSCT could be exploited to cure HIV in cancer patients requiring such procedures. Participants also discussed how HSCT might be applied to a broader community of HIV-infected persons in whom the risks of HSCT currently outweigh the likelihood and benefits of HIV cure.

SUBMITTER: Smiley ST 

PROVIDER: S-EPMC4296106 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Progress toward curing HIV infections with hematopoietic stem cell transplantation.

Smiley Stephen T ST   Singh Anjali A   Read Sarah W SW   Sharma Opendra K OK   Finzi Diana D   Lane Clifford C   Rice Jeffrey S JS  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20141001 2

Combination antiretroviral therapy can suppress human immunodeficiency virus (HIV) infection but cannot completely eradicate the virus. A major obstacle in the quest for a cure is the difficulty in targeting and measuring latently infected cells. To date, a single person seems to have been cured of HIV. Hematopoietic stem cell transplantation (HSCT) preceded this cancer patient's long-term sustained HIV remission, but researchers have been unable to replicate this cure, and the mechanisms that l  ...[more]