Ontology highlight
ABSTRACT:
SUBMITTER: Subramanian N
PROVIDER: S-EPMC4296747 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Subramanian Nithya N Kanwar Jagat R JR Kanwar Rupinder K RK Krishnakumar Subramanian S
Nucleic acid therapeutics 20141216 1
The miR-17∼92. or oncomiR-1, cluster encodes oncogenic microRNAs (miRNAs), and it also promotes retinoblastoma (RB) tumor formation. Antagomir and miRNA mimics based approaches are widely tried against oncogenic and tumor suppressive miRNAs. Other methods for targeting cancer related miRNAs are still under development. In the current study, we focused on the pri-miRNA-17∼92 aptamer (pri-apt), which can potentially replace the mix of five antagomirs by one aptamer that function to abrogate the ma ...[more]