Diet dominates host genotype in shaping the murine gut microbiota.
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ABSTRACT:
SUBMITTER: Carmody RN
PROVIDER: S-EPMC4297240 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Diet dominates host genotype in shaping the murine gut microbiota.
Carmody Rachel N RN Gerber Georg K GK Luevano Jesus M JM Gatti Daniel M DM Somes Lisa L Svenson Karen L KL Turnbaugh Peter J PJ
Cell host & microbe 20141218 1
Mammals exhibit marked interindividual variations in their gut microbiota, but it remains unclear if this is primarily driven by host genetics or by extrinsic factors like dietary intake. To address this, we examined the effect of dietary perturbations on the gut microbiota of five inbred mouse strains, mice deficient for genes relevant to host-microbial interactions (MyD88(-/-), NOD2(-/-), ob/ob, and Rag1(-/-)), and >200 outbred mice. In each experiment, consumption of a high-fat, high-sugar di ...[more]
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