Ontology highlight
ABSTRACT:
SUBMITTER: Schug ZT
PROVIDER: S-EPMC4297291 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Schug Zachary T ZT Peck Barrie B Jones Dylan T DT Zhang Qifeng Q Grosskurth Shaun S Alam Israt S IS Goodwin Louise M LM Smethurst Elizabeth E Mason Susan S Blyth Karen K McGarry Lynn L James Daniel D Shanks Emma E Kalna Gabriela G Saunders Rebecca E RE Jiang Ming M Howell Michael M Lassailly Francois F Thin May Zaw MZ Spencer-Dene Bradley B Stamp Gordon G van den Broek Niels J F NJ Mackay Gillian G Bulusu Vinay V Kamphorst Jurre J JJ Tardito Saverio S Strachan David D Harris Adrian L AL Aboagye Eric O EO Critchlow Susan E SE Wakelam Michael J O MJ Schulze Almut A Gottlieb Eyal E
Cancer cell 20150101 1
A functional genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions. Comparative metabolomics and lipidomics demonstrated that acetate is used as a nutritional source by cancer cells in an ACSS2-dependent manner, and supplied a significant fraction of the carbon within the fatty acid and phospholipid pools. ACSS2 expression is upregulated under metabolically stressed conditions and ACSS2 silenc ...[more]