Ontology highlight
ABSTRACT:
SUBMITTER: Yin J
PROVIDER: S-EPMC4297474 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20111001 10
Multidrug resistance-associated protein 1(MRP1/ABCC1) is the first identified member of ABCC subfamily which belongs to ATP-binding cassette (ABC) transporter superfamily. It is ubiquitously expressed in almost all human tissues and transports a wide spectrum of substrates including drugs, heavy metal anions, toxicants, and conjugates of glutathione, glucuronide and sulfate. With the advance of sequence technology, many MRP1/ABCC1 polymorphisms have been identified. Accumulating evidences show t ...[more]