Test driving ToxCast: endocrine profiling for 1858 chemicals included in phase II.
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SUBMITTER: Filer D
PROVIDER: S-EPMC4297520 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
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Test driving ToxCast: endocrine profiling for 1858 chemicals included in phase II.
Filer Dayne D Patisaul Heather B HB Schug Thaddeus T Reif David D Thayer Kristina K
Current opinion in pharmacology 20141201
Identifying chemicals, beyond those already implicated, to test for potential endocrine disruption is a challenge and high throughput approaches have emerged as a potential tool for this type of screening. This review focused the Environmental Protection Agency's (EPA) ToxCast(TM) high throughput in vitro screening (HTS) program. Utility for identifying compounds was assessed and reviewed by using it to run the recently expanded chemical library (from 309 compounds to 1858) through the ToxPi(TM) ...[more]
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