Ontology highlight
ABSTRACT:
SUBMITTER: Serinagaoglu Y
PROVIDER: S-EPMC4297555 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Serinagaoglu Yelda Y Paré Joshua J Giovannini Marco M Cao Xinwei X
Developmental biology 20141126 1
Molecular mechanisms governing the maintenance and proliferation of dorsal root ganglia (DRG) progenitors are largely unknown. Here we reveal that the Hippo pathway regulates the expansion of DRG progenitors and glia during mammalian DRG development. The key effectors of this pathway, transcriptional coactivators Yap and Taz, are expressed in DRG progenitors and glia during DRG development but are at least partially inhibited from activating transcription. Aberrant YAP activation leads to overex ...[more]