Ontology highlight
ABSTRACT:
SUBMITTER: Shrestha S
PROVIDER: S-EPMC4297581 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Nature immunology 20150105 2
The interplay between effector T cells and regulatory T cells (Treg cells) is crucial for adaptive immunity, but how Treg cells control diverse effector responses is elusive. We found that the phosphatase PTEN links Treg cell stability to repression of type 1 helper T cell (TH1 cell) and follicular helper T cell (TFH cell) responses. Depletion of PTEN in Treg cells resulted in excessive TFH cell and germinal center responses and spontaneous inflammatory disease. These defects were considerably b ...[more]