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Granulocyte-macrophage colony stimulating factor exerts protective and immunomodulatory effects in cortical trauma.

ABSTRACT: Neurodegeneration after traumatic brain injury is facilitated by innate and adaptive immunity and can be harnessed to affect brain repair. In mice subjected to controlled cortical impact (CCI), we show that treatment with granulocyte macrophage colony stimulating factor (GM-CSF) affects regulatory T cell numbers in the cervical lymph nodes coincident with decreased lesion volumes and increased cortical tissue sparing. This paralleled increases in neurofilament and diminished reactive microglial staining. Transcriptomic analysis showed that GM-CSF induces robust immune neuroprotective responses seven days following CCI. Together, these results support the therapeutic potential of GM-CSF for TBI.

SUBMITTER: Kelso ML

PROVIDER: S-EPMC4297700 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Granulocyte-macrophage colony stimulating factor exerts protective and immunomodulatory effects in cortical trauma.

Kelso Matthew L ML Elliott Bret R BR Haverland Nicole A NA Mosley R Lee RL Gendelman Howard E HE

Journal of neuroimmunology 20141107

Neurodegeneration after traumatic brain injury is facilitated by innate and adaptive immunity and can be harnessed to affect brain repair. In mice subjected to controlled cortical impact (CCI), we show that treatment with granulocyte macrophage colony stimulating factor (GM-CSF) affects regulatory T cell numbers in the cervical lymph nodes coincident with decreased lesion volumes and increased cortical tissue sparing. This paralleled increases in neurofilament and diminished reactive microglial ...[more]

PMID: 25468272

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