Ontology highlight
ABSTRACT:
SUBMITTER: Varadharaj S
PROVIDER: S-EPMC4297730 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Varadharaj Saradhadevi S Porter Kyle K Pleister Adam A Wannemacher Jacob J Sow Angela A Jarjoura David D Zweier Jay L JL Khayat Rami N RN
Respiratory physiology & neurobiology 20141219
The mechanism of vascular endothelial dysfunction (VED) and cardiovascular disease in obstructive sleep apnea (OSA) is unknown. We performed a comprehensive evaluation of endothelial nitric oxide synthase (eNOS) function directly in the microcirculatory endothelial tissue of OSA patients who have very low cardiovascular risk status. Nineteen OSA patients underwent gluteal biopsies before, and after effective treatment of OSA. We measured superoxide (O2(•-)) and nitric oxide (NO) in the microcirc ...[more]