Ontology highlight
ABSTRACT:
SUBMITTER: Florence GJ
PROVIDER: S-EPMC4298241 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Florence Gordon J GJ Fraser Andrew L AL Gould Eoin R ER King Elizabeth F B EF Menzies Stefanie K SK Morris Joanne C JC Tulloch Lindsay B LB Smith Terry K TK
ChemMedChem 20140821 11
Neglected tropical diseases remain a serious global health concern. Here, a series of novel bis-tetrahydropyran 1,4-triazole analogues based on the framework of chamuvarinin, a polyketide natural product isolated from the annonaceae plant species are detailed. The analogues synthesized display low micromolar trypanocidal activities towards both bloodstream and insect forms of Trypanosoma brucei, the causative agent of African sleeping sickness, also known as Human African Trypanosomiasis (HAT). ...[more]