Ontology highlight
ABSTRACT:
SUBMITTER: Martin BN
PROVIDER: S-EPMC4298287 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Martin Bradley N BN Wang Chenhui C Willette-Brown Jami J Herjan Tomasz T Gulen Muhammet F MF Zhou Hao H Bulek Katarzyna K Franchi Luigi L Sato Takashi T Alnemri Emad S ES Narla Goutham G Zhong Xiao-Ping XP Thomas James J Klinman Dennis D Fitzgerald Katherine A KA Karin Michael M Nuñez Gabriel G Dubyak George G Hu Yinling Y Li Xiaoxia X
Nature communications 20140930
The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines. Here we report that IκB kinase α (IKKα) is a critical negative regulator of apoptosis-associated specklike protein containing a C-terminal caspase-activation-andrecruitment (CARD) domain (ASC)-dependent inflammasomes. IKKα controls the inflammasome at the level of the adaptor ASC, which interacts with IKKα in the nucleus of resting m ...[more]