Serotonin dysregulation in Fragile X Syndrome: implications for treatment.
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ABSTRACT:
SUBMITTER: Hanson AC
PROVIDER: S-EPMC4298641 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Serotonin dysregulation in Fragile X Syndrome: implications for treatment.
Hanson Alicia C AC Hagerman Randi J RJ
Intractable & rare diseases research 20141101 4
Fragile X Syndrome (FXS) is a trinucleotide repeat disorder that results in the silencing of the Fragile X Mental Retardation 1 gene (FMR1), leading to a lack of the FMR1 protein (FMRP). FMRP is an mRNA-binding protein that regulates the translation of hundreds of mRNAs important for synaptic plasticity. Several of these pathways have been identified and have guided the development of targeted treatments for FXS. Here we present evidence that serotonin is dysregulated in FXS and treatment with t ...[more]
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