Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions.
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ABSTRACT:
SUBMITTER: Otomo T
PROVIDER: S-EPMC4298682 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions.
Otomo Takanobu T Schweizer Michaela M Kollmann Katrin K Schumacher Valéa V Muschol Nicole N Tolosa Eva E Mittrücker Hans-Willi HW Braulke Thomas T
The Journal of cell biology 20150101 2
Antigen processing and presentation and cytotoxic targeting depend on the activities of several lysosomal enzymes that require mannose 6-phosphate (M6P) sorting signals for efficient intracellular transport and localization. In this paper, we show that mice deficient in the formation of M6P residues exhibit significant loss of cathepsin proteases in B cells, leading to lysosomal dysfunction with accumulation of storage material, impaired antigen processing and presentation, and subsequent defect ...[more]
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