Ontology highlight
ABSTRACT:
SUBMITTER: Tang HM
PROVIDER: S-EPMC4298746 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Tang Hei-Man Vincent HM Pan Kewu K Kong Ka-Yiu Edwin KY Hu Ligang L Chan Ling-Chim LC Siu Kam-Leung KL Sun Hongzhe H Wong Chi-Ming CM Jin Dong-Yan DY
Scientific reports 20150120
Ferredoxins are iron-sulfur proteins that play important roles in electron transport and redox homeostasis. Yeast Apd1p is a novel member of the family of thioredoxin-like ferredoxins. In this study, we characterized the hydroxyurea (HU)-hypersensitive phenotype of apd1Δ cells. HU is an inhibitor of DNA synthesis, a cellular stressor and an anticancer agent. Although the loss of APD1 did not influence cell proliferation or cell cycle progression, it resulted in HU sensitivity. This sensitivity w ...[more]