Ontology highlight
ABSTRACT:
SUBMITTER: Snitow ME
PROVIDER: S-EPMC4299135 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Snitow Melinda E ME Li Shanru S Morley Michael P MP Rathi Komal K Lu Min Min MM Kadzik Rachel S RS Stewart Kathleen M KM Morrisey Edward E EE
Development (Cambridge, England) 20150101 1
The development of the lung epithelium is regulated in a stepwise fashion to generate numerous differentiated and stem cell lineages in the adult lung. How these different lineages are generated in a spatially and temporally restricted fashion remains poorly understood, although epigenetic regulation probably plays an important role. We show that the Polycomb repressive complex 2 component Ezh2 is highly expressed in early lung development but is gradually downregulated by late gestation. Deleti ...[more]