Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep.
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ABSTRACT:
SUBMITTER: Van Dort CJ
PROVIDER: S-EPMC4299243 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep.
Van Dort Christa J CJ Zachs Daniel P DP Kenny Jonathan D JD Zheng Shu S Goldblum Rebecca R RR Gelwan Noah A NA Ramos Daniel M DM Nolan Michael A MA Wang Karen K Weng Feng-Ju FJ Lin Yingxi Y Wilson Matthew A MA Brown Emery N EN
Proceedings of the National Academy of Sciences of the United States of America 20141229 2
Rapid eye movement (REM) sleep is an important component of the natural sleep/wake cycle, yet the mechanisms that regulate REM sleep remain incompletely understood. Cholinergic neurons in the mesopontine tegmentum have been implicated in REM sleep regulation, but lesions of this area have had varying effects on REM sleep. Therefore, this study aimed to clarify the role of cholinergic neurons in the pedunculopontine tegmentum (PPT) and laterodorsal tegmentum (LDT) in REM sleep generation. Selecti ...[more]
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