Ontology highlight
ABSTRACT:
SUBMITTER: Zalk R
PROVIDER: S-EPMC4300236 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Zalk Ran R Clarke Oliver B OB des Georges Amédée A Grassucci Robert A RA Reiken Steven S Mancia Filippo F Hendrickson Wayne A WA Frank Joachim J Marks Andrew R AR
Nature 20141201 7532
Ryanodine receptors (RyRs) mediate the rapid release of calcium (Ca(2+)) from intracellular stores into the cytosol, which is essential for numerous cellular functions including excitation-contraction coupling in muscle. Lack of sufficient structural detail has impeded understanding of RyR gating and regulation. Here we report the closed-state structure of the 2.3-megadalton complex of the rabbit skeletal muscle type 1 RyR (RyR1), solved by single-particle electron cryomicroscopy at an overall r ...[more]