Enantioselective oxidative gold catalysis enabled by a designed chiral P,N-bidentate ligand.

ABSTRACT: A newly developed P,N-bidentate ligand enables enantioselective intramolecular cyclopropanation by a reactive ?-oxo gold carbene intermediate generated in situ. The ligand design is based on our previously proposed structure (with a well-organized triscoordinated gold center) of the carbene intermediate in the presence of a P,N-bidentate ligand. A C2-symmetric piperidine ring was incorporated in the ligand as the nitrogen-containing moiety. A range of racemic transformations of ?-oxo gold carbene intermediates have been developed recently, and this new class of chiral ligands could enable their modification for asymmetric synthesis, as demonstrated in this study.

SUBMITTER: Ji K 

PROVIDER: S-EPMC4300284 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature