Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC4300495 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Li Jingjing J Shi Minyi M Ma Zhihai Z Zhao Shuchun S Euskirchen Ghia G Ziskin Jennifer J Urban Alexander A Hallmayer Joachim J Snyder Michael M
Molecular systems biology 20141230
Autism is a complex disease whose etiology remains elusive. We integrated previously and newly generated data and developed a systems framework involving the interactome, gene expression and genome sequencing to identify a protein interaction module with members strongly enriched for autism candidate genes. Sequencing of 25 patients confirmed the involvement of this module in autism, which was subsequently validated using an independent cohort of over 500 patients. Expression of this module was ...[more]