Ontology highlight
ABSTRACT:
SUBMITTER: Barcena C
PROVIDER: S-EPMC4300499 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Bárcena Cristina C Stefanovic Milica M Tutusaus Anna A Martinez-Nieto Guillermo A GA Martinez Laura L García-Ruiz Carmen C de Mingo Alvaro A Caballeria Juan J Fernandez-Checa José C JC Marí Montserrat M Morales Albert A
Scientific reports 20150121
Hepatocellular carcinoma (HCC) frequently develops in a pro-inflammatory and pro-fibrogenic environment with hepatic stellate cells (HSCs) remodeling the extracellular matrix composition. Molecules secreted by liver tumors contributing to HSC activation and peritumoral stromal transformation remain to be fully identified. Here we show that conditioned medium from HCC cell lines, Hep3B and HepG2, induced primary mouse HSCs transdifferentiation, characterized by profibrotic properties and collagen ...[more]