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Evidence of lymphocytic choriomeningitis virus (LCMV) in domestic mice in Gabon: risk of emergence of LCMV encephalitis in Central Africa.

ABSTRACT: Lymphocytic choriomeningitis virus (LCMV) can cause acute fatal disease on all continents but was never detected in Africa. We report the first detection of LCMV RNA in a common European house mouse (Mus musculus domesticus) in Africa. Phylogenetic analyses show a close relationship with North American strains. These findings suggest that there is a risk of the appearance of LCMV acute encephalitis cases. This is a perfect example of virus dissemination by its natural host that may have dramatic public health consequences.

SUBMITTER: N' Dilimabaka N

PROVIDER: S-EPMC4300659 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Evidence of lymphocytic choriomeningitis virus (LCMV) in domestic mice in Gabon: risk of emergence of LCMV encephalitis in Central Africa.

N' Dilimabaka Nadine N Berthet Nicolas N Rougeron Virginie V Mangombi Joa Braïthe JB Durand Patrick P Maganga Gael D GD Bouchier Christiane C Schneider Bradley S BS Fair Joseph J Renaud François F Leroy Eric M EM

Journal of virology 20141105 2

Lymphocytic choriomeningitis virus (LCMV) can cause acute fatal disease on all continents but was never detected in Africa. We report the first detection of LCMV RNA in a common European house mouse (Mus musculus domesticus) in Africa. Phylogenetic analyses show a close relationship with North American strains. These findings suggest that there is a risk of the appearance of LCMV acute encephalitis cases. This is a perfect example of virus dissemination by its natural host that may have dramatic ...[more]

PMID: 25378495

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