Ontology highlight
ABSTRACT:
SUBMITTER: Palsuledesai CC
PROVIDER: S-EPMC4301080 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Palsuledesai Charuta C CC Distefano Mark D MD
ACS chemical biology 20141208 1
Protein prenylation is a ubiquitous covalent post-translational modification found in all eukaryotic cells, comprising attachment of either a farnesyl or a geranylgeranyl isoprenoid. It is essential for the proper cellular activity of numerous proteins, including Ras family GTPases and heterotrimeric G-proteins. Inhibition of prenylation has been extensively investigated to suppress the activity of oncogenic Ras proteins to achieve antitumor activity. Here, we review the biochemistry of the pren ...[more]