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Mild palladium-catalyzed cyanation of (hetero)aryl halides and triflates in aqueous media.

ABSTRACT: A mild, efficient, and low-temperature palladium-catalyzed cyanation of (hetero)aryl halides and triflates is reported. Previous palladium-catalyzed cyanations of (hetero)aryl halides have required higher temperatures to achieve good catalytic activity. This current reaction allows the cyanation of a general scope of (hetero)aryl halides and triflates at 2-5 mol % catalyst loadings with temperatures ranging from rt to 40 °C. This mild method was applied to the synthesis of lersivirine, a reverse transcriptase inhibitor.

SUBMITTER: Cohen DT

PROVIDER: S-EPMC4301087 | biostudies-literature |

REPOSITORIES: biostudies-literature

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