Predictors of resolution and persistence of renal laboratory abnormalities in pediatric HIV infection.
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ABSTRACT:
SUBMITTER: Mitchell CD
PROVIDER: S-EPMC4301405 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Predictors of resolution and persistence of renal laboratory abnormalities in pediatric HIV infection.
Mitchell Charles D CD Chernoff Miriam C MC Seage George R GR Purswani Murli U MU Spiegel Hans M L HM Zilleruelo Gaston G Abitbol Carolyn C Heckman Barbara B Ponce Christopher B CB Oleske James M JM
Pediatric nephrology (Berlin, Germany) 20140824 1
<h4>Background</h4>Among human immunodeficiency virus (HIV)-infected youth, the role of renal disease (RD) and its management has become increasingly important as these children/adolescents mature into young adults. The identification of predictors of abnormal renal laboratory events (RLE) may be helpful in the management of their HIV infection and its associated renal complications.<h4>Methods</h4>Data collected from HIV-infected youth followed for ≥ 48 months were analyzed to identify predicto ...[more]
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2016-07-01 | E-GEOD-83482 | biostudies-arrayexpress
Project description:Targeted HIV cure strategies require definition of the mechanisms that maintain the virus. Here, we tracked HIV replication and the persistence of infected CD4 T cells in individuals with natural virologic control by sequencing viruses, T cell receptor genes, HIV integration sites and cellular transcriptomes. Our results revealed three mechanisms of HIV persistence operating within distinct anatomic and functional compartments. In lymph node, we detected viruses with genetic and transcriptional attributes of active replication in both T follicular helper (TFH) cells and non-TFH memory cells. In blood, we detected inducible proviruses of archival origin among highly differentiated, clonally expanded cells. Linking the lymph node and blood was a small population of circulating cells harboring inducible proviruses of recent origin. Thus, HIV replication in lymphoid tissue, clonal expansion of infected cells, and recirculation of recently infected cells act together to maintain the virus in HIV controllers despite effective antiviral immunity.
2016-07-01 | GSE83482 | GEO
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