Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis.

ABSTRACT:

Objective

To summarize short term outcomes in randomized controlled trials comparing glibenclamide or metformin versus insulin or versus each other in women with gestational diabetes requiring drug treatment.

Design

Systematic review and meta-analysis.

Eligibility criteria for selecting studies

Randomized controlled trials that fulfilled all the following: (1) published as full text; (2) addressed women with gestational diabetes requiring drug treatment; (3) compared glibenclamide v insulin, metformin v insulin, or metformin v glibenclamide; and (4) provided information on maternal or fetal outcomes.

Data sources

Medline, CENTRAL, and Embase were searched up to 20 May 2014.

Outcomes measures

We considered 14 primary outcomes (6 maternal, 8 fetal) and 16

SUBMITTER: Balsells M 

PROVIDER: S-EPMC4301599 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature