The promise and perils of HDAC inhibitors in neurodegeneration.
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ABSTRACT:
SUBMITTER: Didonna A
PROVIDER: S-EPMC4301678 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
The promise and perils of HDAC inhibitors in neurodegeneration.
Didonna Alessandro A Opal Puneet P
Annals of clinical and translational neurology 20141203 1
Histone deacetylases (HDACs) represent emerging therapeutic targets in the context of neurodegeneration. Indeed, pharmacologic inhibition of HDACs activity in the nervous system has shown beneficial effects in several preclinical models of neurological disorders. However, the translation of such therapeutic approach to clinics has been only marginally successful, mainly due to our still limited knowledge about HDACs physiological role particularly in neurons. Here, we review the potential benefi ...[more]
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