Ontology highlight
ABSTRACT:
SUBMITTER: Norris AD
PROVIDER: S-EPMC4302909 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Norris Adam D AD Sundararajan Lakshmi L Morgan Dyan E DE Roberts Zachary J ZJ Lundquist Erik A EA
Development (Cambridge, England) 20141101 22
UNC-6/Netrin is a conserved axon guidance cue that can mediate both attraction and repulsion. We previously discovered that attractive UNC-40/DCC receptor signaling stimulates growth cone filopodial protrusion and that repulsive UNC-40-UNC-5 heterodimers inhibit filopodial protrusion in C. elegans. Here, we identify cytoplasmic signaling molecules required for UNC-6-mediated inhibition of filopodial protrusion involved in axon repulsion. We show that the Rac-like GTPases CED-10 and MIG-2, the Ra ...[more]