The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.
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ABSTRACT:
SUBMITTER: Grozovsky R
PROVIDER: S-EPMC4303234 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
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The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.
Grozovsky Renata R Begonja Antonija Jurak AJ Liu Kaifeng K Visner Gary G Hartwig John H JH Falet Hervé H Hoffmeister Karin M KM
Nature medicine 20141208 1
The hepatic Ashwell-Morell receptor (AMR) can bind and remove desialylated platelets. Here we demonstrate that platelets become desialylated as they circulate and age in blood. Binding of desialylated platelets to the AMR induces hepatic expression of thrombopoietin (TPO) mRNA and protein, thereby regulating platelet production. Endocytic AMR controls TPO expression through Janus kinase 2 (JAK2) and the acute phase response signal transducer and activator of transcription 3 (STAT3) in vivo and i ...[more]
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