Ontology highlight
ABSTRACT:
SUBMITTER: Danoff EJ
PROVIDER: S-EPMC4303321 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Danoff Emily J EJ Fleming Karen G KG
Biochemistry 20141222 2
Outer membrane β-barrel proteins spontaneously fold into lipid bilayers with rates of folding that are strongly influenced by the physical properties of the membrane. We show that folding is accelerated when the bilayer is at the phase transition temperature, because of the coexistence of lipid phase domains and the high degree of defects present at domain boundaries. These results are consistent with previous observations of faster folding into thin and highly curved membranes, which also conta ...[more]