Ontology highlight
ABSTRACT:
SUBMITTER: Troilo A
PROVIDER: S-EPMC4303451 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
EMBO reports 20131230 1
Loss of primary cilia is a key feature of von Hippel-Lindau tumor suppressor (VHL)-associated pathology. Although VHL-deficiency predisposes cells to precipitous cilia disassembly in response to growth factor cues, it does not affect ciliogenesis. Here, using a siRNA-based screen to find genes that are essential for ciliogenesis only in the presence of the VHL tumor suppressor gene product pVHL, we identify ubiquitin-specific protease (USP)8. The pVHL-dependency of USP8 for ciliogenesis is direc ...[more]