Ontology highlight
ABSTRACT:
SUBMITTER: Kwak HJ
PROVIDER: S-EPMC4303526 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Kwak Hyun-Jeong HJ Liu Peng P Bajrami Besnik B Xu Yuanfu Y Park Shin-Young SY Nombela-Arrieta César C Mondal Subhanjan S Sun Yan Y Zhu Haiyan H Chai Li L Silberstein Leslie E LE Cheng Tao T Luo Hongbo R HR
Immunity 20150108 1
The cellular mechanisms controlling infection-induced emergency granulopoiesis are poorly defined. Here we found that reactive oxygen species (ROS) concentrations in the bone marrow (BM) were elevated during acute infection in a phagocytic NADPH oxidase-dependent manner in myeloid cells. Gr1(+) myeloid cells were uniformly distributed in the BM, and all c-kit(+) progenitor cells were adjacent to Gr1(+) myeloid cells. Inflammation-induced ROS production in the BM played a critical role in myeloid ...[more]