Ontology highlight
ABSTRACT:
SUBMITTER: Bertero T
PROVIDER: S-EPMC4303661 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Bertero Thomas T Cottrill Katherine K Krauszman Adrienn A Lu Yu Y Annis Sofia S Hale Andrew A Bhat Balkrishen B Waxman Aaron B AB Chau B Nelson BN Kuebler Wolfgang M WM Chan Stephen Y SY
The Journal of biological chemistry 20141212 4
Pulmonary hypertension (PH) is a complex disorder, spanning several known vascular cell types. Recently, we identified the microRNA-130/301 (miR-130/301) family as a regulator of multiple pro-proliferative pathways in PH, but the true breadth of influence of the miR-130/301 family across cell types in PH may be even more extensive. Here, we employed targeted network theory to identify additional pathogenic pathways regulated by miR-130/301, including those involving vasomotor tone. Guided by the ...[more]