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Persistence and adherence with dementia pharmacotherapy: relevance of patient, provider, and system factors.


ABSTRACT: This paper provides a comprehensive review of studies examining adherence and (or) persistence with dementia pharmacotherapy during the past decade, including a summary of the key patient-, drug-, system-, and provider-level factors associated with these measures. Estimates of adherence and 1-year persistence to these drugs have ranged from 34% to 94% and 35% to 60%, respectively. Though many studies reported nonsignificant associations, there are data suggesting that patient age, sex, ethnoracial background, socioeconomic status, and region-specific reimbursement criteria, as well as the extent and quality of interactions among patients, caregivers, and providers, may influence persistence with pharmacotherapy. As many studies relied on administrative data, limited information was available regarding the relevance of patient's cognitive and functional status or the importance of caregiver involvement or assistive devices to adherence or persistence.

SUBMITTER: Maxwell CJ 

PROVIDER: S-EPMC4304581 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Persistence and adherence with dementia pharmacotherapy: relevance of patient, provider, and system factors.

Maxwell Colleen J CJ   Stock Kathryn K   Seitz Dallas D   Herrmann Nathan N  

Canadian journal of psychiatry. Revue canadienne de psychiatrie 20141201 12


This paper provides a comprehensive review of studies examining adherence and (or) persistence with dementia pharmacotherapy during the past decade, including a summary of the key patient-, drug-, system-, and provider-level factors associated with these measures. Estimates of adherence and 1-year persistence to these drugs have ranged from 34% to 94% and 35% to 60%, respectively. Though many studies reported nonsignificant associations, there are data suggesting that patient age, sex, ethnoraci  ...[more]

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