Ontology highlight
ABSTRACT:
SUBMITTER: Cekanova M
PROVIDER: S-EPMC4304679 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Cekanova Maria M Fernando Romaine I RI Siriwardhana Nalin N Sukhthankar Mugdha M Parra Columba de la C Woraratphoka Jirayus J Malone Christine C Ström Anders A Baek Seung J SJ Wade Paul A PA Saxton Arnold M AM Donnell Robert M RM Pestell Richard G RG Dharmawardhane Suranganie S Wimalasena Jay J
Experimental cell research 20141209 1
We have previously demonstrated that the anti-apoptotic protein BAD is expressed in normal human breast tissue and shown that BAD inhibits expression of cyclin D1 to delay cell-cycle progression in breast cancer cells. Herein, expression of proteins in breast tissues was studied by immunohistochemistry and results were analyzed statistically to obtain semi-quantitative data. Biochemical and functional changes in BAD-overexpressing MCF7 breast cancer cells were evaluated using PCR, reporter assay ...[more]