YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress.
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ABSTRACT:
SUBMITTER: Rainbolt TK
PROVIDER: S-EPMC4304733 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
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YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress.
Rainbolt T Kelly TK Saunders Jaclyn M JM Wiseman R Luke RL
EMBO reports 20141127 1
Mitochondrial proteostasis is maintained by a network of ATP-dependent quality control proteases including the inner membrane protease YME1L. Here, we show that YME1L is a stress-sensitive mitochondrial protease that is rapidly degraded in response to acute oxidative stress. This degradation requires reductions in cellular ATP and involves the activity of the ATP-independent protease OMA1. Oxidative stress-dependent reductions in YME1L inhibit protective YME1L-dependent functions and increase ce ...[more]
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