Conserved abundance and topological features in chromatin-remodeling protein interaction networks.
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ABSTRACT:
SUBMITTER: Sardiu ME
PROVIDER: S-EPMC4304735 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Conserved abundance and topological features in chromatin-remodeling protein interaction networks.
Sardiu Mihaela E ME Gilmore Joshua M JM Groppe Brad D BD Herman Damir D Ramisetty Sreenivasa R SR Cai Yong Y Jin Jingji J Conaway Ronald C RC Conaway Joan W JW Florens Laurence L Washburn Michael P MP
EMBO reports 20141126 1
The study of conserved protein interaction networks seeks to better understand the evolution and regulation of protein interactions. Here, we present a quantitative proteomic analysis of 18 orthologous baits from three distinct chromatin-remodeling complexes in Saccharomyces cerevisiae and Homo sapiens. We demonstrate that abundance levels of orthologous proteins correlate strongly between the two organisms and both networks have highly similar topologies. We therefore used the protein abundance ...[more]
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