Ontology highlight
ABSTRACT:
SUBMITTER: Hoekstra JG
PROVIDER: S-EPMC4305181 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Hoekstra Jake G JG Cook Travis J TJ Stewart Tessandra T Mattison Hayley H Dreisbach Max T MT Hoffer Zachary S ZS Zhang Jing J
The American journal of pathology 20141204 2
Mitochondrial dynamics has recently become an area of piqued interest in neurodegenerative disorders, including Parkinson disease (PD); however, the contribution of astrocytes to these disorders remains unclear. Here, we show that the level of dynamin-like protein 1 (Dlp1; official name DNM1L), which promotes mitochondrial fission, is lower in astrocytes from the brains of PD patients, and that decreased astrocytic Dlp1 likely represents a relatively early event in PD pathogenesis. In support of ...[more]