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Furosemide versus ethacrynic acid in pediatric patients undergoing cardiac surgery: a randomized controlled trial.


ABSTRACT: Clinical effects of furosemide (F) and ethacrynic acid (EA) continuous infusion on urine output (UO), fluid balance, and renal, cardiac, respiratory, and metabolic function were compared in infants undergoing surgery for congenital heart diseases.A prospective randomized double-blinded study was conducted. Patients received 0.2 mg/kg/h (up to 0.8 mg/kg/h) of either F or EA.In total, 38 patients were enrolled in the F group, and 36, in the EA group. No adverse reactions were recorded. UO at postoperative day (POD) 0 was significantly higher in the EA group, 6.9 (3.3) ml/kg/h, compared with the F group, 4.6 (2.3) ml/kg/h (P?=?0.002) but tended to be similar in the two groups thereafter. Mean administered F dose was 0.33 (0.19) mg/kg/h compared with 0.22 (0.13) mg/kg/h of EA (P?

SUBMITTER: Ricci Z 

PROVIDER: S-EPMC4305226 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Furosemide versus ethacrynic acid in pediatric patients undergoing cardiac surgery: a randomized controlled trial.

Ricci Zaccaria Z   Haiberger Roberta R   Pezzella Chiara C   Garisto Cristiana C   Favia Isabella I   Cogo Paola P  

Critical care (London, England) 20150107


<h4>Introduction</h4>Clinical effects of furosemide (F) and ethacrynic acid (EA) continuous infusion on urine output (UO), fluid balance, and renal, cardiac, respiratory, and metabolic function were compared in infants undergoing surgery for congenital heart diseases.<h4>Methods</h4>A prospective randomized double-blinded study was conducted. Patients received 0.2 mg/kg/h (up to 0.8 mg/kg/h) of either F or EA.<h4>Results</h4>In total, 38 patients were enrolled in the F group, and 36, in the EA g  ...[more]

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