Ontology highlight
ABSTRACT:
SUBMITTER: Lesan V
PROVIDER: S-EPMC4305376 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Lesan Vahid V Ghaffari Seyed H SH Salaramoli Jamile J Heidari Mansour M Rostami Masoumeh M Alimoghaddam Kamran K Ghavamzadeh Ardeshir A
International journal of hematology-oncology and stem cell research 20140701 3
Metformin has recently been introduced as an anti-cancer agent. In this study, we evaluated the effect of metformin and metformin/cisplatin on human gastric MKN-45 cell line. When we used metformin alone, it could inhibit proliferation and induce apoptosis, but it diminish anti-proliferative effects of cisplatin when they are used in combination. Further, we checked mRNA levels of survivin, mTOR, and Akt by real-time PCR. When MKN-45 cells were treated with metformin/cisplatin, the expression of ...[more]