Ontology highlight
ABSTRACT:
SUBMITTER: Anderson SR
PROVIDER: S-EPMC4305468 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Anderson Sarah R SR Lee Inyoul I Ebeling Christine C Stephenson Dennis A DA Schweitzer Kelsey M KM Baxter David D Moon Tara M TM LaPierre Sarah S Jaques Benjamin B Silvius Derek D Wegner Michael M Hood Leroy E LE Carlson George G Gunn Teresa M TM
Mammalian genome : official journal of the International Mammalian Genome Society 20141116 1-2
Mice homozygous for the gray tremor (gt) mutation have a pleiotropic phenotype that includes pigmentation defects, megacolon, whole body tremors, sporadic seizures, hypo- and dys-myelination of the central nervous system (CNS) and peripheral nervous system, vacuolation of the CNS, and early death. Vacuolation similar to that caused by prions was originally reported to be transmissible, but subsequent studies showed the inherited disease was not infectious. The gt mutation mapped to distal mouse ...[more]