Ontology highlight
ABSTRACT:
SUBMITTER: Parchem RJ
PROVIDER: S-EPMC4305531 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Parchem Ronald J RJ Ye Julia J Judson Robert L RL LaRussa Marie F MF Krishnakumar Raga R Blelloch Amy A Oldham Michael C MC Blelloch Robert R
Cell stem cell 20140313 5
Ectopic expression of specific factors such as Oct4, Sox2, and Klf4 (OSK) is sufficient to reprogram somatic cells into induced pluripotent stem cells (iPSCs). In this study, we examine the paths taken by cells during the reprogramming process by following the transcriptional activation of two pluripotent miRNA clusters (mir-290 and mir-302) in individual cells in vivo and in vitro with knockin reporters. During embryonic development and embryonic stem cell differentiation, all cells sequentiall ...[more]