Uncertainty of prebiotic scenarios: the case of the non-enzymatic reverse tricarboxylic acid cycle.
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ABSTRACT:
SUBMITTER: Zubarev DY
PROVIDER: S-EPMC4306138 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Uncertainty of prebiotic scenarios: the case of the non-enzymatic reverse tricarboxylic acid cycle.
Zubarev Dmitry Yu DY Rappoport Dmitrij D Aspuru-Guzik Alán A
Scientific reports 20150126
We consider the hypothesis of the primordial nature of the non-enzymatic reverse tricarboxylic acid (rTCA) cycle and describe a modeling approach to quantify the uncertainty of this hypothesis due to the combinatorial aspect of the constituent chemical transformations. Our results suggest that a) rTCA cycle belongs to a degenerate optimum of auto-catalytic cycles, and b) the set of targets for investigations of the origin of the common metabolic core should be significantly extended. ...[more]
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